| Year | Team | CMP | ATT | YDS | CMP% | YPA | TD | INT | LNG | SACK | RTG | CAR | YDS | AVG | TD | LNG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025 | BUF | 25 | 35 | 313 | 71.4 | 8.9 | 4 | - | 83 | - | 137.0 | 9 | 6 | 0.7 | - | 12 |
| 2024 | BUF | 19 | 26 | 179 | 73.1 | 6.9 | 2 | - | 98 | - | 117.3 | 17 | 1 | 0.1 | - | 6 |
| 2023 | PIT | 67 | 107 | 632 | 62.6 | 5.9 | 4 | 5 | 106 | 7 | 366.2 | 16 | 54 | 3.4 | 2 | 30 |
| 2022 | PIT | 117 | 180 | 1252 | 65.0 | 7.0 | 4 | 5 | 242 | 11 | 590.8 | 19 | 38 | 2.0 | 2 | 33 |
| 2021 | BUF | 6 | 8 | 43 | 75.0 | 5.4 | - | 1 | 32 | - | 326.3 | 13 | 24 | 1.9 | 1 | 28 |
| 2020 | CHI | 199 | 297 | 2055 | 67.0 | 6.9 | 16 | 8 | 268 | 18 | 841.0 | 33 | 196 | 5.9 | 1 | 130 |
| 2019 | CHI | 326 | 516 | 3138 | 63.2 | 6.1 | 17 | 10 | 465 | 38 | 1259.3 | 48 | 193 | 4.0 | 2 | 98 |
| 2018 | CHI | 289 | 434 | 3223 | 66.6 | 7.4 | 24 | 12 | 544 | 24 | 1322.9 | 68 | 421 | 6.2 | 3 | 208 |
| 2017 | CHI | 196 | 330 | 2193 | 59.4 | 6.7 | 7 | 7 | 398 | 31 | 979.4 | 41 | 248 | 6.0 | 2 | 149 |