| # | Player | PASS YDS |
|---|---|---|
| 1 | Matthew StaffordLAR • QB | 4707 |
| 2 | Jared GoffDET • QB | 4564 |
| 3 | Dak PrescottDAL • QB | 4552 |
| 4 | Drake MayeNE • QB | 4394 |
| 5 | Sam DarnoldSEA • QB | 4048 |
| 6 | Trevor LawrenceJAX • QB | 4007 |
| 7 | Caleb WilliamsCHI • QB | 3942 |
| 8 | Bo NixDEN • QB | 3931 |
| 9 | Justin HerbertLAC • QB | 3727 |
| 10 | Baker MayfieldTB • QB | 3693 |