Player | CAR | YDS | TD | AVG |
|---|---|---|---|---|
  James Cook BUF Bills | 39 | 163 | 0 | 4.2 |
  Kyren Williams LAR Rams | 34 | 144 | 2 | 4.2 |
  D'Andre Swift CHI Bears | 32 | 130 | 1 | 4.1 |
  Woody Marks HOU Texans | 33 | 129 | 1 | 3.9 |
  Rhamondre Stevenson NE Patriots | 26 | 123 | 0 | 4.7 |
  Kenneth Walker SEA Seahawks | 19 | 116 | 3 | 6.1 |
  Saquon Barkley PHI Eagles | 26 | 106 | 0 | 4.1 |
  Christian McCaffrey SF 49ers | 26 | 83 | 0 | 3.2 |
  Travis Etienne JAX Jaguars | 10 | 67 | 0 | 6.7 |
 Blake Corum LAR Rams | 17 | 64 | 0 | 3.8 |
 Kyle Monangai CHI Bears | 21 | 63 | 0 | 3.0 |
 Nick Chubb HOU Texans | 14 | 62 | 0 | 4.4 |
  Josh Jacobs GB Packers | 19 | 55 | 0 | 2.9 |
 TreVeyon Henderson NE Patriots | 21 | 52 | 0 | 2.5 |
 Bhayshul Tuten JAX Jaguars | 4 | 51 | 0 | 12.8 |
  Chuba Hubbard CAR Panthers | 13 | 46 | 2 | 3.5 |
  Jaylen Warren PIT Steelers | 12 | 43 | 0 | 3.6 |
  Kimani Vidal LAC Chargers | 11 | 31 | 0 | 2.8 |
 Jordan James SF 49ers | 6 | 28 | 0 | 4.7 |
  Jaleel McLaughlin DEN Broncos | 4 | 21 | 0 | 5.3 |
 RJ Harvey DEN Broncos | 6 | 20 | 0 | 3.3 |
 Kenneth Gainwell PIT Steelers | 6 | 20 | 0 | 3.3 |
 Zach Charbonnet SEA Seahawks | 5 | 20 | 0 | 4.0 |
 Tank Bigsby PHI Eagles | 4 | 19 | 0 | 4.8 |
 Chris Brooks GB Packers | 1 | 16 | 0 | 16.0 |
 Velus Jones SEA Seahawks | 6 | 10 | 0 | 1.7 |
 Rico Dowdle CAR Panthers | 5 | 9 | 0 | 1.8 |
 Trevor Etienne CAR Panthers | 1 | 4 | 0 | 4.0 |
 Brian Robinson SF 49ers | 3 | 4 | 0 | 1.3 |
 Emanuel Wilson GB Packers | 1 | 3 | 0 | 3.0 |
 LeQuint Allen JAX Jaguars | 1 | 3 | 0 | 3.0 |