| Year | Team | CMP | ATT | YDS | CMP% | YPA | TD | INT | LNG | SACK | RTG | CAR | YDS | AVG | TD | LNG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025 | IND | 58 | 92 | 544 | 63.0 | 5.9 | 4 | 3 | 68 | 5 | 80.2 | 2 | -1 | -0.5 | - | -1 |
| 2020 | IND | 369 | 543 | 4169 | 68.0 | 7.7 | 24 | 11 | 613 | 19 | 1572.3 | 18 | -8 | -0.4 | - | -1 |
| 2019 | LAC | 390 | 591 | 4615 | 66.0 | 7.8 | 23 | 20 | 669 | 34 | 1472.0 | 12 | 29 | 2.4 | - | 29 |
| 2018 | LAC | 347 | 508 | 4308 | 68.3 | 8.5 | 32 | 12 | 627 | 32 | 1691.4 | 18 | 7 | 0.4 | - | 13 |
| 2017 | LAC | 360 | 575 | 4515 | 62.6 | 7.8 | 28 | 10 | 675 | 18 | 1543.1 | 18 | -2 | -0.1 | - | 10 |
| 2016 | SD | 349 | 578 | 4386 | 60.4 | 7.6 | 33 | 21 | 715 | 36 | 1442.7 | 14 | 35 | 2.5 | - | 30 |
| 2015 | SD | 437 | 661 | 4792 | 66.1 | 7.3 | 29 | 13 | 664 | 40 | 1494.7 | 17 | 28 | 1.6 | - | 25 |
| 2014 | SD | 379 | 570 | 4286 | 66.5 | 7.6 | 31 | 18 | 557 | 36 | 1500.0 | 37 | 102 | 3.2 | - | 84 |
| 2013 | SD | 378 | 544 | 4478 | 69.5 | 8.2 | 32 | 11 | 594 | 30 | 1685.0 | 28 | 72 | 2.6 | - | 68 |
| 2012 | SD | 338 | 527 | 3606 | 64.1 | 7.1 | 26 | 15 | 574 | 49 | 1494.3 | 27 | 40 | 1.4 | - | 40 |
| 2011 | SD | 366 | 582 | 4624 | 62.9 | 8.3 | 27 | 20 | 619 | 30 | 1483.8 | 26 | 36 | 0.8 | 1 | 35 |
| 2010 | SD | 357 | 541 | 4710 | 66.0 | 9.1 | 30 | 13 | 648 | 38 | 1683.2 | 29 | 52 | 2.1 | - | 60 |
| 2009 | SD | 317 | 486 | 4254 | 65.2 | 8.8 | 28 | 9 | 657 | 25 | 1696.9 | 26 | 50 | 2.1 | 1 | 43 |