Player | GP | ATT | YDS | TD | YPA | |
|---|---|---|---|---|---|---|
  | Isiah Pacheco KC Chiefs | 4 | 81 | 313 | 3 | 3.86 |
  | Christian McCaffrey SF 49ers | 3 | 59 | 268 | 4 | 4.54 |
  | Aaron Jones GB Packers | 2 | 39 | 226 | 3 | 5.79 |
  | David Montgomery DET Lions | 3 | 39 | 183 | 2 | 4.69 |
 | Jahmyr Gibbs DET Lions | 3 | 29 | 144 | 3 | 4.97 |
  | James Cook BUF Bills | 2 | 36 | 140 | 0 | 3.89 |
  | Rachaad White TB Buccaneers | 2 | 27 | 127 | 0 | 4.7 |
  | Devin Singletary HOU Texans | 2 | 22 | 88 | 1 | 4 |
  | Justice Hill BAL Ravens | 2 | 16 | 69 | 0 | 4.31 |
 | Ty Johnson BUF Bills | 2 | 15 | 66 | 0 | 4.4 |
  | Kyren Williams LAR Rams | 1 | 13 | 61 | 0 | 4.69 |
 | Gus Edwards BAL Ravens | 2 | 13 | 60 | 0 | 4.62 |
  | Tony Pollard DAL Cowboys | 1 | 15 | 56 | 1 | 3.73 |
 | Clyde Edwards-Helaire KC Chiefs | 4 | 11 | 53 | 0 | 4.82 |
  | Jaylen Warren PIT Steelers | 1 | 8 | 38 | 0 | 4.75 |
 | Najee Harris PIT Steelers | 1 | 12 | 37 | 0 | 3.08 |
 | Emanuel Wilson GB Packers | 2 | 12 | 36 | 0 | 3 |
  | D'Andre Swift PHI Eagles | 1 | 10 | 34 | 0 | 3.4 |
  | Raheem Mostert MIA Dolphins | 1 | 8 | 33 | 0 | 4.13 |
 | Chase Edmonds TB Buccaneers | 2 | 11 | 31 | 0 | 2.82 |
  | Kareem Hunt CLE Browns | 1 | 8 | 26 | 1 | 3.25 |
 | Dalvin Cook BAL Ravens | 1 | 8 | 23 | 0 | 2.88 |
 | Jerome Ford CLE Browns | 1 | 9 | 17 | 0 | 1.89 |
 | Elijah Mitchell SF 49ers | 3 | 6 | 15 | 1 | 2.5 |
 | Rico Dowdle DAL Cowboys | 1 | 2 | 11 | 0 | 5.5 |
 | Ronnie Rivers LAR Rams | 1 | 3 | 9 | 0 | 3 |
 | De'Von Achane MIA Dolphins | 1 | 6 | 9 | 0 | 1.5 |
 | Dare Ogunbowale HOU Texans | 2 | 2 | 7 | 0 | 3.5 |
 | Patrick Taylor GB Packers | 2 | 3 | 6 | 0 | 2 |
 | Kyle Juszczyk SF 49ers | 3 | 2 | 5 | 0 | 2.5 |
 | Kenneth Gainwell PHI Eagles | 1 | 4 | 3 | 0 | 0.75 |
 | Craig Reynolds DET Lions | 3 | 1 | 1 | 1 | 1 |