“Filed to ESPN: Andrew Luck has informed the Colts he is retiring from the NFL, per source. There will be a press conference Sunday to make it official, but Luck is mentally worn down, and now checking out.”

Vikings RB Aaron Jones is on the sideline with a hip injury.

49ers RB Christian McCaffrey won’t return for TNF against Seattle in Week 6, when he is eligible to come off IR, per @AdamSchefter

Saints TE Taysom Hill (rib) has been ruled out for Week 5.

The Packers have placed WR Romeo Doubs on the reserve/suspended list for one game for conduct detrimental to the team, per @AdamSchefter

Jaguars TE Evan Engram (hamstring) is not tracking to play Sunday vs. the Colts, per @JFowlerESPN

The Cardinals have downgraded TE Trey McBride (ribs) to questionable for Sunday’s game, per @MikeGarafolo

Colts QB Anthony Richardson (hip/oblique) has been downgraded to doubtful, per @AdamSchefter

The Patriots are activating WR Kendrick Bourne from the PUP list and he’ll make his season debut Sunday against the Dolphins, per @TomPelissero