“Filed to ESPN: Andrew Luck has informed the Colts he is retiring from the NFL, per source. There will be a press conference Sunday to make it official, but Luck is mentally worn down, and now checking out.”

49ers RB Christian McCaffrey won’t return for TNF against Seattle in Week 6, when he is eligible to come off IR, per @AdamSchefter

Saints TE Taysom Hill (rib) has been ruled out for Week 5.

The Packers have placed WR Romeo Doubs on the reserve/suspended list for one game for conduct detrimental to the team, per @AdamSchefter

Jaguars TE Evan Engram (hamstring) is not tracking to play Sunday vs. the Colts, per @JFowlerESPN

The Cardinals have downgraded TE Trey McBride (ribs) to questionable for Sunday’s game, per @MikeGarafolo

Colts QB Anthony Richardson (hip/oblique) has been downgraded to doubtful, per @AdamSchefter

The Patriots are activating WR Kendrick Bourne from the PUP list and he’ll make his season debut Sunday against the Dolphins, per @TomPelissero

The Cowboys (knee) have placed WR Brandin Cooks on IR, per @AdamSchefter